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Total synthesis of R-(+)-patulolide A and R-(−)-patulolide B: The macrolides isolated from Penicillium urticae mutant

✍ Scribed by Dipak Kalita; Abu Taleb Khan; Nabin C Barua; Ghanashyam Bez


Book ID
108379312
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
459 KB
Volume
55
Category
Article
ISSN
0040-4020

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Chemoenzymatic Synthesis of (R)-(+)-Patu
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## Abstract (__R__)‐(+)‐Patulolide A [(__R__)‐1] was synthesized with an enantiomeric purity of almost 100% e.e. by a two‐step lipase‐catalyzed enantioselective hydrolysis of racemic thioketal acetate (±)‐11.

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✍ Mori, Kenji ;Sakai, Teruyuki 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 535 KB

An enantioselective synthesis of patulolide A (1). patulolide B (2). and pdtulolide C (3) from ethyl (R)-3-bydroxybutanoate is described. Recently Yamada and his co-workers isolated three new antimicrobial macrolides from the culture broth of Penicil- lium urticae mutant S11R59, named them patuloli