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Chemoenzymatic Synthesis of (R)-(+)-Patulolide A, a Macrolide Antibiotic Isolated from Penicillium urticae

✍ Scribed by Kitamura, Masaya ;Nagaoka, Hiroyuki ;Naoshima, Yoshinobu ;Kamezawa, Makoto ;Tachibana, Hojun ;Ohtani, Takehiko

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 377 KB
Volume: 1996
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.199619960204

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✦ Synopsis

Abstract

(R)‐(+)‐Patulolide A [(R)‐1] was synthesized with an enantiomeric purity of almost 100% e.e. by a two‐step lipase‐catalyzed enantioselective hydrolysis of racemic thioketal acetate (±)‐11.

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