Total Synthesis of Proposed Amphidinolide A via a Highly Selective Ring-Closing Metathesis
β Scribed by Maleczka,, Robert E.; Terrell, Lamont R.; Geng, Feng; Ward, Joseph S.
- Book ID
- 120200634
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 99 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A.
Racemic and enantiopure targets containing the 6,8-dioxabicycio [3.2.1]octane skeleton, can be conveniently synthesized from monocyclic diene precursors using an intramolecular ruthenium-catalyzed ring-closing metathesis reaction as the key step.
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