Diospyrol 4 is constructed from a masked butadiene synthon. anthracene adduct 1 [R = H]. The key construction steps comprise tandem Michael addition-Dieckmann condensations, first between anion 7 and 1 , and subsequently between anion 7 and 15. ln the previous communication 1 we described a straigh
Total Synthesis of (-)-Praziquantel: An Anthelmintic Drug.
β Scribed by Chen Ma; Qian-Feng Zhang; Ye-Bang Tan; Long Wang
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 25 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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Cytotrienin A (1) is a microbial antitumor secondary metabolite that was isolated from the fermentation broth of Streptomyces sp. RK95-74 from soil. [1] It possesses an E,E,E-triene motif within a 21-membered cyclic lactam, which also contains four chiral centers. These are common structural feature
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