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The Asymmetric Total Synthesis of (+)-Cytotrienin A, an Ansamycin-Type Anticancer Drug

✍ Scribed by Yujiro Hayashi; Mitsuru Shoji; Hayato Ishikawa; Junichiro Yamaguchi; Tomohiro Tamura; Hiroki Imai; Yosuke Nishigaya; Kenichi Takabe; Hideaki Kakeya; Hiroyuki Osada

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
370 KB
Volume
47
Category
Article
ISSN
0044-8249

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The Asymmetric Total Synthesis of (+)-Cy
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Cytotrienin A (1) is a microbial antitumor secondary metabolite that was isolated from the fermentation broth of Streptomyces sp. RK95-74 from soil. [1] It possesses an E,E,E-triene motif within a 21-membered cyclic lactam, which also contains four chiral centers. These are common structural feature

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v