Total synthesis of diospyrol an anthelmintic drug from diospyros mollis griff

✍ Scribed by C. Mahidol; B. Tarnchompoo; C. Thebtaranonth; Y. Thebtaranonth

• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 195 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)80678-x

✦ Synopsis

Diospyrol 4 is constructed from a masked butadiene synthon. anthracene adduct 1 [R = H].

The key construction steps comprise tandem Michael addition-Dieckmann condensations, first between anion 7 and 1 , and subsequently between anion 7 and 15. ln the previous communication 1 we described a straightforward synthesis of deepoxy-4,5-didehydrmethyleno