The evolution of bacteria with resistance towards clinically used antibiotics requires constant efforts in the search for new antibacterial compounds to target these menacing strains. [1] Recent advances in screening technologies allowed a team of scientists at Merck to develop and employ a target-b
Total Synthesis of (±)-Platencin
✍ Scribed by Yoshimitsu, Takehiko; Nojima, Shoji; Hashimoto, Masashi; Tanaka, Tetsuaki
- Book ID
- 127050360
- Publisher
- American Chemical Society
- Year
- 2011
- Tongue
- English
- Weight
- 1017 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1523-7060
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## Abstract **Der richtige Bicyclus**: Die effiziente sauerstoffvermittelte palladiumkatalysierte Cycloalkenylierung von **1** zu einem Bicyclo[3.2.1]octan und die desoxygenierende Umlagerung des Tosylhydrazons **2** zum Bicyclo[2.2.2]octan **3** sind wesentliche Schritte der Synthese der Kernstruk
## Abstract **The right bicycle**: A concise formal synthesis of platencin was based on an efficient oxygen‐mediated palladium‐catalyzed cycloalkenylation of **1** to form a bicyclo[3.2.1]octane, and a deoxygenative rearrangement of tosylhydrazone **2** to construct the bicyclo[2.2.2]octane **3**.