Total Synthesis of Octalactin A and B
β Scribed by Buszek, Keith R.; Sato, Nagaaki; Jeong, Youngmee
- Book ID
- 120968600
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 266 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A.
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