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Total Synthesis of Myriocin.

โœ Scribed by Kee-Young Lee; Chang-Young Oh; Yong-Hyun Kim; Jae-Eun Joo; Won-Hun Ham


Book ID
101938629
Publisher
John Wiley and Sons
Year
2003
Weight
56 KB
Volume
34
Category
Article
ISSN
0931-7597

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Total synthesis of myriocin
โœ Kee-Young Lee; Chang-Young Oh; Yong-Hyun Kim; Jae-Eun Joo; Won-Hun Ham ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 211 KB

A concise, stereocontrolled synthesis of myriocin was achieved. Key features involve diastereoselective oxazoline formation catalyzed by palladium(0), MgBr 2 -promoted allylic stannane addition, and palladium(0)-catalyzed coupling of a vinyl iodide with an organozinc reagent.