Stereoselective total synthesis of (+)-myriocin from d-mannose
โ Scribed by Oishi, Takeshi; Ando, Koji; Chida, Noritaka
- Book ID
- 120395213
- Publisher
- Royal Society of Chemistry
- Year
- 2001
- Tongue
- English
- Weight
- 80 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1359-7345
- DOI
- 10.1039/b104864n
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๐ SIMILAR VOLUMES
A concise, stereocontrolled synthesis of myriocin was achieved. Key features involve diastereoselective oxazoline formation catalyzed by palladium(0), MgBr 2 -promoted allylic stannane addition, and palladium(0)-catalyzed coupling of a vinyl iodide with an organozinc reagent.
The chiral and stereoselective synthesis of (+)-lactacystin 1, the first non-protein neurotrophic factor having an ct,~t-disubstituted a-amino acid structure, is described. The highly functionalized y-lactam portion possessing a tetra-substituted carbon with nitrogen in I was effectively constructed