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Total synthesis of mycophenolic acid

✍ Scribed by Danheiser, Rick L.; Gee, Stephen K.; Perez, Joseph J.


Book ID
121267948
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
682 KB
Volume
108
Category
Article
ISSN
0002-7863

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Total synthesis of mycophenolic acid
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A total convergent synthesis of mycophenolic acid 1 from 2-geranyldimethyl-l,3-acetonedicarboxylate 2 and 4-pivaloyloxy-2-butynal using a Michael addition-Dieckmann cyclization as key step is described.

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