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A total synthesis of mycophenolic acid

✍ Scribed by Adrián Covarrubias-Zúñiga; Armando González-Lucas

Book ID: 104259101
Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 107 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00423-7

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✦ Synopsis

A total convergent synthesis of mycophenolic acid 1 from 2-geranyldimethyl-l,3-acetonedicarboxylate 2 and 4-pivaloyloxy-2-butynal using a Michael addition-Dieckmann cyclization as key step is described.

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