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Total synthesis of methynolide

✍ Scribed by Ditrich, Klaus

Book ID: 102901327
Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 527 KB
Volume: 1990
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.1990199001147

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✦ Synopsis

Abstract

In this paper the synthesis of methynolide (1), the aglycone of methymycin, a 12‐membered macrolide antibiotic is described. We have used the chiral C‐1 to C‐8 segment 10 which has been combined with the C‐9 to C‐13 segment 9 to form the carbon skeleton of methynolide. Cyclization of the seco‐acid 14 has been accomplished by intramolecular esterification.

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