Total Synthesis of Methotrexate-γ-TRIS-Fatty Acid Conjugates.
✍ Scribed by Craig L. Francis; Qi Yang; Noel K. Hart; Fred Widmer; Michael K. Manthey; H. Ming He-Williams
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 60 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The total synthesis, in chiral form, of unsaturated trlhydroxy Clg fatty acids 13 and 14 as methyl esters, s&ting from natural tartaric acid via the key intermediate aldehyde 5 is reported. Little is known about the biological importance of oxygenated fatty acids metabolitcs in vegetals. Then, it
~ummary: Dnsymmetrical onoceranoid triterpenes, .,y-onoceradienedione and lansic acid, have been synthesized effectively by means of mercury(I1) triflate/ amine complex-induced olefin cyclization. A variety of unsymmetrical onocerane type triterpenes, such as a,Y-onoceradienedione (Il, "\* lansic a
The furanoid fatty acid F 5 has been synthesized using a mercury(ll) catalyzed isomerization of 2-(1,2-oxiranylcyclododecyl)-3-nonyn-2-ol.
The hitherto unknown (±)-4-methoxydecanoic acid was synthesized in six steps and in 25% overall yield starting from commercially available 4-penten-1-ol. The title compound demonstrated seventeen fold higher antifungal activity (MIC = 1.5 mM) against Candida albicans ATCC 60193 and Cryptococcus. neo