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Total synthesis of (.+-.)-maytansinol. The common precursor to the maytansinoids

✍ Scribed by Meyers, A. I.; Reider, Paul J.; Campbell, Arthur L.


Book ID
121312475
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
259 KB
Volume
102
Category
Article
ISSN
0002-7863

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πŸ“œ SIMILAR VOLUMES


Studies related to the synthesis of mayt
✍ Derek H.R. Barton; Michel BΓ©nΓ©chie; FranΓ§oise Khuong-Huu; Pierre Potier; Victor πŸ“‚ Article πŸ“… 1982 πŸ› Elsevier Science 🌐 French βš– 196 KB

Two approaches to the partial synthesis of C1-Cs of a bis-nor maytansinoid 1 have been investigated starting on the one hand with (S)-(-)-malic acid and on the other, with D-(+)-ribonolactone. 2 Maytansinoids are interesting naturally occurringIantitumor agents . 3 Extensive work has already been ca

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Methanophenazine is a new cofactor from methanogenic archaea. (S)-Methanophenazine has been synthesized from three building blocks, i.e. 2-hydroxy-phenazine, ethyl (R)-3-methylglutarate and (E,E)farnesyl acetone; a stereodivergent approach from ethyl (R)-3-methylglutarate warrants the formal synthes