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Progress toward the total synthesis of maytansinoids. A facile route to the aromatic moiety (western zone)

โœ Scribed by John M. Kane; A.I. Meyers


Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
164 KB
Volume
18
Category
Article
ISSN
0040-4039

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Progress toward the total synthesis of m
โœ A.I. Meyers; C.C. Shaw; Deane Horne; L.M. Trefonas; R.J. Majeste ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 174 KB

The complex structure of the potent anti-leukemic ansa macrolide, maytansine (3,' undoubtedly presents a formidable synthetic challenge. We have recently reported2 the preparation of the cyclic carbinolamide gwhich represents the so-called "eastern zone" of maytansine. In this communication we wis