Progress toward the total synthesis of maytansine. A model system containing the C-7 to C-16 moiety (southern and eastern zone)

Progress toward the total synthesis of m

Progress toward the total synthesis of maytansine. A stereoselective synthesis of the C-1 to C-7 moiety (northern zone)

✍ A.I. Meyers; C.C. Shaw; Deane Horne; L.M. Trefonas; R.J. Majeste 📂 Article 📅 1975 🏛 Elsevier Science 🌐 French ⚖ 174 KB

The complex structure of the potent anti-leukemic ansa macrolide, maytansine (3,' undoubtedly presents a formidable synthetic challenge. We have recently reported2 the preparation of the cyclic carbinolamide gwhich represents the so-called "eastern zone" of maytansine. In this communication we wis