A short, efficient and stereoselective synthesis of a furofuran lignan, (±)-sesamin, has been achieved in good overall yield through the radical cyclisation of an epoxide using a Ti(III) reagent as the radical initiator.
Total synthesis of (±)-laurene and epilaurene by radical cyclisation reaction
✍ Scribed by A. Srikrishna; G. Sunderbabu
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 133 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Total synthesis of (+)-laurene and epilaurene, via the radical cyclisation of the xanthate (11) derived from the ace-tylenic alcohol (lo), is described.
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