Total Synthesis of l -Biopterin from l -Tartaric Acid via 5-Deoxy- l -arabinose
β Scribed by Fernandez, Anne-Marie; Duhamel, Lucette
- Book ID
- 120643677
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 196 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
## Abstract A simple synthesis of 5βdeoxyβLβ[5β^2^H~1~]arabinose was performed to obtain Lβ[3β²β^2^H~1~]biopterin. The reduced form of this model substance is needed to investigate the pathway of 7βsubstituted pterins in patients with primapterinuria.
Polyoxamic acid , 2-amino-2-deoxy-L-xylonic acid, is synthetized by thiophenoxide opening of a five-carbon chiral hydroxylated aziridine easily derived from L-arabinose. The formation of the carboxy group resulted lrom a Pummerer reaction. Polyoxins belong to a group of antifungal antibiotics produc