ChemInform Abstract: Synthesis of Dioxol
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O. NEUSS; B. FURMAN; Z. KALUZA; M. CHMIELEWSKI
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Article
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2010
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John Wiley and Sons
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Synthesis of Dioxolanylclavam from Tartaric Acid. -(2 + 2) Cycloaddition of the 3-O-vinyl ether (I) derived from tartaric acid to chlorosulfonyl isocyanate (II) gives the 4-alkoxyazetidinone ( III) with good diastereoselectivity. Cyclization provides the clavam ( IV) missing the C-3 carboxylic funct