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Total Synthesis of Garsubellin A

โœ Scribed by Siegel, Dionicio R.; Danishefsky, Samuel J.


Book ID
125542685
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
58 KB
Volume
128
Category
Article
ISSN
0002-7863

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Total Synthesis of Garsubellin A.
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During studies directed toward the total synthesis of garsubellin A, synthesis of 8-deprenyl-garsubellin A, containing three (of four in the natural product) stereocenters with the proper configurations, was achieved. Key steps are a one-pot lactone formation, a formal migration to the bicyclo[3.3.1