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Stereoselective total synthesis of garsubellin A

โœ Scribed by Uwamori, Masahiro; Nakada, Masahisa


Book ID
120448203
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
857 KB
Volume
66
Category
Article
ISSN
0021-8820

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During studies directed toward the total synthesis of garsubellin A, synthesis of 8-deprenyl-garsubellin A, containing three (of four in the natural product) stereocenters with the proper configurations, was achieved. Key steps are a one-pot lactone formation, a formal migration to the bicyclo[3.3.1