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Studies toward the Total Synthesis of Garsubellin A: A Concise Synthesis of the 18- epi -Tricyclic Core

โœ Scribed by Usuda, Hiroyuki; Kanai, Motomu; Shibasaki, Masakatsu


Book ID
127026569
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
73 KB
Volume
4
Category
Article
ISSN
1523-7060

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Studies toward the total synthesis of ga
โœ Hiroyuki Usuda; Motomu Kanai; Masakatsu Shibasaki ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 165 KB

During studies directed toward the total synthesis of garsubellin A, synthesis of 8-deprenyl-garsubellin A, containing three (of four in the natural product) stereocenters with the proper configurations, was achieved. Key steps are a one-pot lactone formation, a formal migration to the bicyclo[3.3.1