Total Synthesis of Ezetimibe, a Cholesterol Absorption Inhibitor
✍ Scribed by Śnieżek, Marcin; Stecko, Sebastian; Panfil, Irma; Furman, Bartłomiej; Chmielewski, Marek
- Book ID
- 120494781
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 822 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
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The lipid lowering agent ezetimibe (EZ) and its intestinally formed glucuronide (GLUC) were shown to be substrates of the efflux transporters P-glycoprotein (P-gp) and the multidrug resistance associated protein 2 (MRP2) which markedly influences the disposition and efficacy of EZ in man. This study