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Pharmacodynamic interaction between fenofibrate and the cholesterol absorption inhibitor ezetimibe

✍ Scribed by Kosoglou, T.; Guillaume, M.; Sun, S.; Pember, L.J.C.; Reyderman, L.; Statkevich, P.; Cutler, D.L.; Veltri, E.P.; Affrime, M.B.


Book ID
118630115
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
124 KB
Volume
2
Category
Article
ISSN
1567-5688

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The lipid lowering agent ezetimibe (EZ) and its intestinally formed glucuronide (GLUC) were shown to be substrates of the efflux transporters P-glycoprotein (P-gp) and the multidrug resistance associated protein 2 (MRP2) which markedly influences the disposition and efficacy of EZ in man. This study