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The novel cholesterol absorption inhibitor, ezetimibe, selectively inhibits the intestinal absorption of free cholesterol in the presence and absence of exocrine pancreatic function

โœ Scribed by M. van Heek; C. Farley; D. Compton; L. Hoos; H. Davis


Book ID
119434897
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
172 KB
Volume
151
Category
Article
ISSN
0021-9150

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Disposition of the cholesterol absorptio
โœ Stefan Oswald; Christiane Koll; Werner Siegmund ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 150 KB

The lipid lowering agent ezetimibe (EZ) and its intestinally formed glucuronide (GLUC) were shown to be substrates of the efflux transporters P-glycoprotein (P-gp) and the multidrug resistance associated protein 2 (MRP2) which markedly influences the disposition and efficacy of EZ in man. This study