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Ezetimibe: A First-in-Class, Novel Cholesterol Absorption Inhibitor

✍ Scribed by Lipka, Leslie J.

Book ID
109106103
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
224 KB
Volume
21
Category
Article
ISSN
0897-5957

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πŸ“œ SIMILAR VOLUMES

Disposition of the cholesterol absorptio
Disposition of the cholesterol absorption inhibitor ezetimibe in mdr1a/b (βˆ’/βˆ’) mice
✍ Stefan Oswald; Christiane Koll; Werner Siegmund πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 150 KB

The lipid lowering agent ezetimibe (EZ) and its intestinally formed glucuronide (GLUC) were shown to be substrates of the efflux transporters P-glycoprotein (P-gp) and the multidrug resistance associated protein 2 (MRP2) which markedly influences the disposition and efficacy of EZ in man. This study