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Total Synthesis of Epothilone A through Stereospecific Epoxidation of the p-Methoxybenzyl Ether of Epothilone C

โœ Scribed by Zhi-Yu Liu; Ze-Cheng Chen; Cheng-Zhi Yu; Rui-Fang Wang; Ru-Zhou Zhang; Chu-Sheng Huang; Zheng Yan; De-Rong Cao; Jian-Bo Sun; Gang Li


Book ID
101368839
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
229 KB
Volume
8
Category
Article
ISSN
0947-6539

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The Formal Total Synthesis of Epothilone
โœ Markus Kalesse; Monika Quitschalle; Eckhard Claus; Kai Gerlach; Axel Pahl; Hartm ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 347 KB ๐Ÿ‘ 2 views

The formal total synthesis of epothilone A is described. The 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reactio