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Total Synthesis of Dehydrodidemnin B. Use of Uronium and Phosphonium Salt Coupling Reagents in Peptide Synthesis in Solution†

✍ Scribed by Jou, Gemma; González, Isabel; Albericio, Fernando; Lloyd-Williams, Paul; Giralt, Ernest


Book ID
111937765
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
484 KB
Volume
62
Category
Article
ISSN
0022-3263

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On the use of PyAOP, a phosphonium salt
✍ Fernando Albericio; Marta Cases; Jordi Alsina; Salvatore A. Triolo; Louis A. Car 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 293 KB

Phosphonium derivatives of HOAt such as PyAOP are useful for the solid-phase preparation of a range of peptides that include those incorporating hindered amino acids, difficult short sequences, and cyclic peptides. An advantage relative to uronium salts is that excess PyAOP does not undergo the detr