✦ LIBER ✦

On the use of PyAOP, a phosphonium salt derived from HOAt, in solid-phase peptide synthesis

✍ Scribed by Fernando Albericio; Marta Cases; Jordi Alsina; Salvatore A. Triolo; Louis A. Carpino; Steven A. Kates

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 293 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01011-3

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✦ Synopsis

Phosphonium derivatives of HOAt such as PyAOP are useful for the solid-phase preparation of a range of peptides that include those incorporating hindered amino acids, difficult short sequences, and cyclic peptides. An advantage relative to uronium salts is that excess PyAOP does not undergo the detrimental side-reaction at the amino terminus which blocks further chain assembly.

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