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A study on the use of phenylacetyl disulfide in the solid-phase synthesis of oligodeoxynucleoside phosphorothioates

✍ Scribed by H. C. P. F. Roelen; P. C. J. Kamer; H. van den Elst; G. A. van der Marel; J. H. van Boom

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 737 KB
Volume: 110
Category: Article
ISSN: 0165-0513
DOI: 10.1002/recl.19911100705

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✦ Synopsis

Abstract

Sulfurization of protected [i.e., 2‐cyanoethyl, methyl and 2‐(4‐nitrophenyl)ethyl] internucleosidic phosphite triesters can be conveniently executed with the easily accessible reagent, phenylacetyl disulfide (1). High‐quality oligodeoxynucleotides containing predetermined combinations of natural and phosphorothioate linkages can be obtained via a solid‐phase approach by using reagent 1 and 2‐(4‐nitrophenyl)ethyl‐protected phosphoramidites.

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