𝔖 Bobbio Scriptorium
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Total synthesis of curacin A

✍ Scribed by Michael Z. Hoemann; Konstantinos A. Agrios; Jeffrey Aubé


Book ID
103404371
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
189 KB
Volume
37
Category
Article
ISSN
0040-4039

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📜 SIMILAR VOLUMES


Asymmetric total synthesis of curacin A
✍ Toshihiko Onoda; Ryuichi Shirai; Yukiko Koiso; Shigeo Iwasaki 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 230 KB
Total synthesis of (+)-curacin A, a mari
✍ Michael Z. Hoemann; Konstantinos A. Agrios; Jeffrey Aubé 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 865 KB

The total synthesis of curacin A, a cytotoxic agent that interacts with the colchicine binding site on tubulin, is described. The convergent synthesis utilizes natural product and chiral pool starting materials (geraniol, serine) and asymmetric synthesis (chiral allylborane addition, Charette cyclop