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Asymmetric total synthesis of curacin A

โœ Scribed by Toshihiko Onoda; Ryuichi Shirai; Yukiko Koiso; Shigeo Iwasaki


Book ID
103408190
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
230 KB
Volume
37
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


Total synthesis of curacin A
โœ Michael Z. Hoemann; Konstantinos A. Agrios; Jeffrey Aubรฉ ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 189 KB
Total synthesis of (+)-curacin A, a mari
โœ Michael Z. Hoemann; Konstantinos A. Agrios; Jeffrey Aubรฉ ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 865 KB

The total synthesis of curacin A, a cytotoxic agent that interacts with the colchicine binding site on tubulin, is described. The convergent synthesis utilizes natural product and chiral pool starting materials (geraniol, serine) and asymmetric synthesis (chiral allylborane addition, Charette cyclop