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Total Synthesis of the Antimitotic Marine Natural Product (+)-Curacin A

โœ Scribed by Wipf, Peter; Xu, Wenjing


Book ID
121245087
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
334 KB
Volume
61
Category
Article
ISSN
0022-3263

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Total synthesis of (+)-curacin A, a mari
โœ Michael Z. Hoemann; Konstantinos A. Agrios; Jeffrey Aubรฉ ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 865 KB

The total synthesis of curacin A, a cytotoxic agent that interacts with the colchicine binding site on tubulin, is described. The convergent synthesis utilizes natural product and chiral pool starting materials (geraniol, serine) and asymmetric synthesis (chiral allylborane addition, Charette cyclop