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Total Synthesis of Bryostatins: The Development of Methodology for the Atom-Economic and Stereoselective Synthesis of the Ring C Subunit

✍ Scribed by Prof. Dr. Barry M. Trost; Prof. Dr. Alison J. Frontier; Dr. Oliver R. Thiel; Dr. Hanbiao Yang; Dr. Guangbin Dong

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
540 KB
Volume
17
Category
Article
ISSN
0947-6539

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Total Syntheses of Bryostatins: Synthesis of Two Ring-Expanded Bryostatin Analogues and the Development of a New-Generation Strategy to Access the C7–C27 Fragment
✍ Dr. Barry M. Trost; Dr. Hanbiao Yang; Dr. Guangbin Dong 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 1019 KB

## Abstract Herein, we report the synthesis of novel ring‐expanded bryostatin analogues. By carefully modifying the substrate, a selective and high‐yielding Ru‐catalyzed tandem enyne coupling/Michael addition was employed to construct the northern fragment. Ring‐closing metathesis was utilized to f