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ChemInform Abstract: Total Synthesis of Bryostatins: The Development of Methodology for the Atom-Economic and Stereoselective Synthesis of the Ring C Subunit.

✍ Scribed by Barry M. Trost; Alison J. Frontier; Oliver R. Thiel; Hanbiao Yang; Guangbin Dong


Publisher
John Wiley and Sons
Year
2011
Weight
18 KB
Volume
43
Category
Article
ISSN
0931-7597

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Total Syntheses of Bryostatins: Synthesi
✍ Dr. Barry M. Trost; Dr. Hanbiao Yang; Dr. Guangbin Dong πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 1019 KB

## Abstract Herein, we report the synthesis of novel ring‐expanded bryostatin analogues. By carefully modifying the substrate, a selective and high‐yielding Ru‐catalyzed tandem enyne coupling/Michael addition was employed to construct the northern fragment. Ring‐closing metathesis was utilized to f