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Atom-Economic and Stereoselective Syntheses of the Ring A and B Subunits of the Bryostatins

✍ Scribed by Prof. Barry M. Trost; Dr. Hanbiao Yang; Dr. Cheyenne S. Brindle; Dr. Guangbin Dong


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
595 KB
Volume
17
Category
Article
ISSN
0947-6539

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Total Syntheses of Bryostatins: Synthesi
✍ Dr. Barry M. Trost; Dr. Hanbiao Yang; Dr. Guangbin Dong πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 1019 KB

## Abstract Herein, we report the synthesis of novel ring‐expanded bryostatin analogues. By carefully modifying the substrate, a selective and high‐yielding Ru‐catalyzed tandem enyne coupling/Michael addition was employed to construct the northern fragment. Ring‐closing metathesis was utilized to f