Total synthesis of anthramycin nears
- Book ID
- 126512168
- Publisher
- American Chemical Society
- Year
- 1966
- Tongue
- English
- Weight
- 877 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0009-2347
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๐ SIMILAR VOLUMES
Linked analogs of the DNA binding antibiotic anthramycin are made via nucleophilic aromatic substitution followed by reduction-cyclization. The linked compounds protect DNA from restriction en&m&eases and reversibly crosslink DNA.
Hydride reduction of pyrrolo[1,4]benzodiazepine-5,lO-diones to carbinolamines is possible if a sufficiently electron-withdrawing group is present on the aromatic ring; the X-ray structure of one such product is given.
Anthramycin and actinomycin D, two different types of DNAbinding antibiotics, were compared for their effects on RNA synthesis in suspension cultures of mouse leukemia L1210 cells. RNA was labeled with radioactive uridine and selective effects on the synthesis of different classes of RNA were studie