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Synthesis and dna crosslinking ability of a dimeric anthramycin analog

✍ Scribed by J.Dean Farmer Jr.; Suzanne M. Rudnicki; J. William Suggs

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
250 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis

Linked analogs of the DNA binding antibiotic anthramycin are made via nucleophilic aromatic substitution followed by reduction-cyclization. The linked compounds protect DNA from restriction en&m&eases and reversibly crosslink DNA.

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