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Total Synthesis of (−)- and (+)-Dysibetaine

✍ Scribed by Snider, Barry B.; Gu, Yonghong


Book ID
126903942
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
55 KB
Volume
3
Category
Article
ISSN
1523-7060

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An Ugi Reaction in the Total Synthesis o
✍ Jerry Isaacson; Yoshihisa Kobayashi 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 295 KB 👁 2 views

## Abstract **(−)‐Dysibetaine has been synthesized** in 11 steps from readily available L‐malic acid (see scheme). The key step is a unique Ugi 4‐center‐3‐component cyclization reaction, where an ester group acts as the carboxylic acid component. The use of 1,1,1,3,3,3‐hexamethyldisilazane as an am