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Total Synthesis of Amphidinolide T4

✍ Scribed by Alois Fürstner; Christophe Aïssa; Ricardo Riveiros; Jacques Ragot


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
154 KB
Volume
41
Category
Article
ISSN
0044-8249

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Total Synthesis of Amphidinolide T4.
✍ Alois Fuerstner; Christophe Aissa; Ricardo Riveiros; Jacques Ragot 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 66 KB
A Concise Total Synthesis of Amphidinoli
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RCM + AD = T2: In the presence of the C16-methylene group, regioselective ring-closing metathesis (RCM) formed the (12E)-endocyclic double bond, which underwent Os-catalyzed asymmetric dihydroxylation (AD) to give the desired 12,13-diol intermediate required for the total synthesis of amphidinolide

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## Abstract For Abstract see ChemInform Abstract in Full Text.

Total Synthesis of (−)-Amphidinolide E
✍ Chan Hyuk Kim; Hyo Jung An; Won Kyo Shin; Wei Yu; Sang Kook Woo; Soon Kyu Jung; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB 👁 1 views

Amphidinolide E (1) is a unique 18-membered macrolide isolated from the Y-5' strain of the dinoflagellate Amphidinium sp. [1] It exhibits cytotoxic activity against L1210 (IC 50 = 2.0 mg mL À1 ) and L5178Y (IC 50 = 4.8 mg mL À1 ) murine leukemia cells in vitro. Owing to its unique structural feature