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Enantioselective Total Synthesis of (+)-Amphidinolide T1.

✍ Scribed by Arun K. Ghosh; Chunfeng Liu

Publisher: John Wiley and Sons
Year: 2003
Weight: 67 KB
Volume: 34
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200327186

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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Amphidinolide E (1) is a unique 18-membered macrolide isolated from the Y-5' strain of the dinoflagellate Amphidinium sp. [1] It exhibits cytotoxic activity against L1210 (IC 50 = 2.0 mg mL À1 ) and L5178Y (IC 50 = 4.8 mg mL À1 ) murine leukemia cells in vitro. Owing to its unique structural feature