𝔖 Bobbio Scriptorium
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A Concise Total Synthesis of Amphidinolide T2

✍ Scribed by Dr. Huoming Li; Dr. Jinlong Wu; Dr. Jialu Luo; Prof. Dr. Wei-Min Dai

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
223 KB
Volume
16
Category
Article
ISSN
0947-6539

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✦ Synopsis

RCM + AD = T2: In the presence of the C16-methylene group, regioselective ring-closing metathesis (RCM) formed the (12E)-endocyclic double bond, which underwent Os-catalyzed asymmetric dihydroxylation (AD) to give the desired 12,13-diol intermediate required for the total synthesis of amphidinolide T2 in 16 linear steps in 8.0% overall yield.

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