Total Synthesis of (−)-Amphidinolide E
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Chan Hyuk Kim; Hyo Jung An; Won Kyo Shin; Wei Yu; Sang Kook Woo; Soon Kyu Jung;
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Article
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2006
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John Wiley and Sons
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English
⚖ 117 KB
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Amphidinolide E (1) is a unique 18-membered macrolide isolated from the Y-5' strain of the dinoflagellate Amphidinium sp. [1] It exhibits cytotoxic activity against L1210 (IC 50 = 2.0 mg mL À1 ) and L5178Y (IC 50 = 4.8 mg mL À1 ) murine leukemia cells in vitro. Owing to its unique structural feature