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Total synthesis of a potent immunosuppressant pironetin

โœ Scribed by Mukund K Gurjar; John T Henri Jr.; D Subhas Bose; A V Rama Rao


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
218 KB
Volume
37
Category
Article
ISSN
0040-4039

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The convergent total synthesis of (-)-pironetin using a chiral building block, (1S,5S,6R)- 5hydroxybicyclo[4.1.0]heptan-2-one 5 is described. Both the dithiane 4 and the epoxide 2 with proper substituents were employed as coupling partners to construct the whole carbon skeleton 15, which was convert