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Total Synthesis of a New Cytotoxic Acetogenin, Jimenezin, and the Revised Structure

โœ Scribed by Takahashi, Shunya; Maeda, Katsuya; Hirota, Shinsuke; Nakata, Tadashi


Book ID
126985265
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
57 KB
Volume
1
Category
Article
ISSN
1523-7060

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โœ James A. Marshall; Kevin W. Hinkle ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 284 KB

The total synthesis of (+)-(30s)bullanin, a highly cytotoxic Annonaceous acetogenin, was effected by a convergent approach in which the key core his-2,2'-tetrahydrofuran stereocenters were introduced through a combination of Sharpless asymmetric dihydroxylation and S,2' additions of oxygenated nonra