Total synthesis of 9(O)-methanoprostacyclin and its isomers
โ Scribed by Koichi Kojima; Kiyoshi Sakai
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- French
- Weight
- 219 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The first total synthesii of the highly unstable biological medistor 12-ket&coss&etr~ic acid (12-KBTB) 3 and its 89-traas -isoma tp is presented. The strategy focuses on the stable precursor dithiane u and its ccnwzsion to gand 211. Bicchemical experiments show that the two isomers are net interccmv
## Previous studies by Kabachnik and co-workers' have shown, by the The relative rate of reaction4 of sodium 0,0-(1) and sodium O,Sdimethylphosphorodithioate (2) (determined by allowing a mixture of the two sodium salts to compete for a deficiency of methyl iodide-d3) was determined by NMR spectro