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Total synthesis of 5(S),15(S)-dihydroxy-6,13-trans-8,15-cis-eicosatetraenoic acid (5,15-diHETE) and 8(S),15(S)-dihydroxy-5,11-cis-9,13-trans-eicosatetraenoic acid (8,15-DiHETE), two novel metabolites of arachidonic acid

โœ Scribed by Nicolaou, K. C.; Webber, S. E.


Book ID
126117876
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
393 KB
Volume
106
Category
Article
ISSN
0002-7863

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A stereoselective and practical synthesi
โœ E.J. Corey; Mukund M. Mehrotra ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 267 KB

A stereoselective synthesis of 4, a possible biosynthetic precursor of lipoxins, is reported. A pathway is suggested by which 4 can give rise to the biologically active lipoxins 1 and 2. In 1984 Serhan, Hamberg and Samuelsson reported that human leukocytes convert 15(S)-