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Total synthesis of (.+-.)-5,6-oxido-7,9-trans,11,14-cis-eicosapentaenoic acid, a possible precursor of SRSA

✍ Scribed by Corey, E. J.; Arai, Yoshinobu; Mioskowski, Charles

Book ID: 126094706
Publisher: American Chemical Society
Year: 1979
Tongue: English
Weight: 302 KB
Volume: 101
Category: Article
ISSN: 0002-7863
DOI: 10.1021/ja00516a045

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## Abstract 5(S)‐Hydroxy‐6(R)‐(N‐[1‐^11^C]acetyl)cysteinyl‐7,9‐trans‐11,14‐cis‐eicosatetraenoic acid (N‐[1‐^11^C]acetyl leukotriene E~4~) was prepared by the reaction of leukotriene E~4~ and [1‐^11^C]acetyl chloride. The product was obtained with 1.3% yield, based on [1‐^11^C]acetyl chloride. The p