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Total synthesis of 5-desoxyleukotriene D. A new and useful equivalent of the 4-formyl-trans, trans-1,3-butadienyl anion

✍ Scribed by E.J. Corey; Dennis J. Hoover

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 292 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)87642-x

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✦ Synopsis

The first total synthesis of 5-desoxyleukotriene D (g) is reported. The route of synthesis utilizes a novel method for five-carbon chain extension. The availability of 1,4 allowed experimental demonstration that the 5-hydroxyl function is important for biological activity of the slow reacting substances.

The slow reacting substances, leukotrienes C, D, and E, are of considerable interest as a new family of highly active biological regulators which also can serve as mediators of pathological states such

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